Salvianolic acid B (SAB, Sal B) is the adumbrative basic of phenolic acids acquired from the broiled base and base of Salvia miltiorrhiza Bge (Labiatae) which has been acclimated broadly and auspiciously in Asian countries for analytic analysis of assorted vascular disturbance-related diseases for hundreds of years. However, its exact cardioprotective apparatus and the basal apparatus for ameliorative base are still ailing understood.
Salvianolic acid B is a corpuscle careful antioxidant and chargeless abolitionist scavenger getting advised for a array of altitude from ischemic affection disorders to Alzheimer′s disease. Several mechanisms of action accept been proposed including EGFR, PDGF and MMP-9 inhibition and inhibition of the TGF-β1/Smads and NF-κB signaling pathways. Salvianolic acid B acts as scavengers of acknowledging oxygen species, reduces the adherence of leukocytes to endothelial cells, inhibits cast metalloproteinases and inflammation. It has cardioprotective furnishings as it reduces lipid peroxidation in damaged cardiac tissue and decreases the arising of lactic acid dehydrogenase.
from:Natural standard substance

Triethyl phosphonoacetate is a reagent for amoebic amalgam acclimated in the Horner-Wadsworth-Emmons acknowledgment (HWE) or the Horner-Emmons modification.
Triethyl phosphonoacetate can be added dropwise to sodium methoxide band-aid to adapt a phosphonate ylide. It has an acerb proton that can calmly be absent by a anemic base. If acclimated in an HWE acknowledgment with a carbonyl the consistent alkene formed is usually the E alkene, and is generated with accomplished regioselectivity.
Horner-Emmons-Wadsworth reagent afresh acclimated in the amalgam of chiral 2-methylcyclopropanecarboxylic acerbic from (S)-propylene oxide.
Reactant complex in:
• Horner-Wadsworth-Emmons reactions
• Intramolecular Heck-type cyclization and isomerizations
• Tsuji-Trost blazon reactions
• Intramolecular aryne-ene reactions
• Amalgam of aldehydes
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Gypenosides (Gyp) are the above apparatus of Gynostemma pentaphyllum Makino, a Chinese medical plant. Recently, Gyp has been credible to abet corpuscle aeon arrest and apoptosis in abounding beastly blight corpuscle lines. However, there is no accessible advice to abode the furnishings of Gyp on DNA accident and DNA repair-associated gene announcement in beastly articulate blight cells. Therefore, we advised whether Gyp induced DNA accident and DNA adjustment gene announcement in beastly articulate blight SAS cells. The after-effects from breeze cytometric appraisal adumbrated that Gyp-induced cytotoxic furnishings led to a abatement in the allotment of applicable SAS cells. The after-effects from comet appraisal appear that the evolution of SAS beef with Gyp led to a best DNA clearing apply (comet tail) if compared with ascendancy and this aftereffect was dose-dependent. The after-effects from real-time PCR assay adumbrated that assay of SAS beef with 180 mug/ml of Gyp for 24 h led to a abatement in 14-3-3sigma, DNA-dependent serine/threonine protein kinase (DNAPK), p53, anarchy telangiectasia mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and breast blight gene 1 (BRCA1) mRNA expression. These observations may explain the corpuscle afterlife acquired by Gyp in SAS cells. Taken together, Gyp induced DNA accident and inhibited DNA repair-associated gene expressions in beastly articulate blight SAS beef in vitro.
Gypenosides are saponins abstract acquired from Gynostemma pentaphyllum Makino, aswell accepted as Jiaogulan. Gypenosides accept been acclimated for alleviative hepatitis and blight in Asia, decidedly China. They arrest the access and advance the accretion of alarmist fibrosis induced by CCl(4) in rats.
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Diosgenin is a plant steroid which induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells.
Synonym: 3β-Hydroxy-5-spirostene; (25R)-5-Spirosten-3β-ol
Application: A steroid sapogenin with estrogenic activity
CAS Number: 512-04-9
Purity: 98%
Molecular Weight: 414.62
Molecular Formula: C27H42O3
Description
Diosgenin is a steroid sapogenin used in the semi-synthesis of pregnenolone, cortisone, and progesterone. Diosgenin has estrogenic activity and can reduce the level of serum cholesterol.
Technical Information
Appearance: Crystalline
Physical State: Solid
Solubility: Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), DMSO (<1 mg/ml at 25 °C), and methanol.
Storage: Store at room temperature
Melting Point: 203.9-207.2 °C

Lead is a soft, adaptable and adaptable metal. It has an affluence in the earth's band of 14 ppm., the capital antecedent of the metal getting the ore "galena", Lead (II) sulphide (PbS) which occurs as blah cubic crystals, about in affiliation with "sphalerite", the agnate sulphide of zinc.
Lead oxidises readily in clammy air, is abiding to oxygen and water, but dissolves in nitric acid. It is a poor electrical and thermal aqueduct but has reasonable bane resistance. Applications for this metal are Lead and varied; for example, its about compactness to radiation makes it ideal as radiation careful absolute for use with X-ray equipment. Lead is aswell acclimated in bowl glazes, batteries, paints, as a armament accretion in petrol (lead tetraethyl) and as a prime basic of bendable solders. However, its use is now getting beat as Lead is now accepted to be adverse to health, decidedly to that of children.
Lead Powder, which is basically acclimated in oil and gas assay and metal bowl composites and can aswell be acclimated in medical field, nuclear and accurate areas.
Highly densified, polycrystalline photoconductors can be bogus by hot-pressing delicate Lead monoxide. Such photoconductors will display added assimilation of radiation, added signal-to-noise ratios, and bigger spatial abundance responses
Lead powder is aswell acclimated for the alertness of apprenticed and affirmed sputtering targets and in Actinic Vapor Deposition (CVD) systems.
from:Rare Metals

Ispinesib is a potent, reversible, allosteric and specific smalll atom inhibitor of kinesin arbor protein (KSP). acquired from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin arbor protein (KSP), consistent in inhibition of mitotic arbor assembly, consecration of corpuscle aeon arrest during the mitotic phase, and corpuscle afterlife in bump beef that are actively dividing. Because KSP is not circuitous in nonmitotic processes, such as neuronal transport, ispinesib may be beneath acceptable to could could cause the borderline neuropathy generally associated with the tubulin-targeting agents. Check for alive analytic trials or bankrupt analytic trials appliance this agent.
Movement is belted by inhibiting ADP absolution afterwards altering the absolution of the KSP-ADP circuitous from the microtubule. Ispinesib shows almighty anticancer properties.
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Application: Which induces differentiation without growth inhibition and apoptosis in B16
name:Saikosaponin C
CAS Number: 20736-08-7
Molecular Weight: 927.12
Molecular Formula: C48H78O18
Storage: Store at -20° C.
Description
In cell culture studies, saikosaponins have been found to induce differentiation without growth inhibition and apoptosis in B16.
from:Natural standard substance

Category: Food and Feed additives/Feed additives
name:Calcium Butyrate
CAS   : 5743-36-2
Molecular Formula: C8H14CaO4
Molecular Weight: 214.2724
Product description:
Specification:Feed grade
Calcium butyrate has the formulaC8H14CaO4,  It is the calcium salt of Butyric acid.
Uses:
 As feed additive in feed industry.
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Tyrosol is a phenolic compound present in two of the traditional components of the Mediterranean diet: wine and virgin olive oil. The presence of tyrosol has been described in red and white wines. Tyrosol is also present in vermouth and beer. Tyrosol has been shown to be able to exert antioxidant activity in in vitro studies. Oxidation of low-density lipoprotein (LDL) appears to occur predominantly in arterial intima in microdomains sequestered from antioxidants of plasma. The antioxidant content of the LDL particle is critical for its protection. Thus, phenolics, which are able to bind LDL, could be effective in preventing lipid peroxidation and atherosclerotic processes. The ability of tyrosol to bind human LDL has been reported. We have demonstrated the bioavailability of tyrosol in humans from virgin olive oil in its natural form. Urinary tyrosol increased, reaching a peak at 0-4 h after virgin olive oil administration. Men and women showed a different pattern of urinary excretion of tyrosol. Moreover, tyrosol is absorbed in a dose-dependent manner after sustained and moderate doses of virgin olive oil. In summary, our results suggest that tyrosol from wine or virgin olive oil could exert beneficial effects on human health in vivo if its biological properties are confirmed in in vivo studies.
from:Natural standard substance

Pazopanib is an anticancer medicine that is used to treat adults with kidney cancer (advanced renal cell carcinoma). It is also used to treat advanced soft tissue sarcoma (STS) in patients who have received cancer treatments.
Pazopanib interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by pazopanib, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.
This drug is a type of targeted therapy known as a known as a kinase inhibitor. Kinases are proteins on or near the surface of a cell that transmit signals to the cell’s control center. Pazopanib inhibits several kinase proteins (VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-A, PDGFR-B, FGFR-1, FGFR-3, Kit, Itk, Lck, and c-Fms). These proteins either prompt tumor cells to grow and divide or help form new blood vessels (angiogenesis) that feed the tumor. By blocking these proteins, pazopanib may help stop the growth of cancer cells.
from:Acridine Raw Material