Vandetanib oral absorption is slow, extend the widely distributed, combined with plasma proteins, metabolic 2 chamber model. Healthy volunteers final 10 days half-life, drug metabolism in patients with more slowly than healthy volunteers, terminal has a half-life of about 20 days. Vandetanib slower, mainly through the excrement and urine, 21 days 69% cleared from the body. Eating had no obvious effect on drug metabolism.
Adverse reactions: 300 mg/d or less well tolerated, the most common side effects are diarrhea, rash, nausea, high blood pressure, anorexia, asymptomatic long QT and proteinuria. With the increase of dose, low phosphate concentration may occur, folliculitis, transaminase eleations, nonspecific intestinal obstruction, reduced platelet, congestive heart failure, deep vein thrombosis, pulmonary embolism, etc. The most common dose limiting toxicity (DLTs) is diarrhea, high blood pressure, and rash.
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From:Natural herbal extracts