Anti-IL-1 α( Interleukin-1 α) bearing beef IL-1 is mainly produced by macrophages; in addition, about all nucleated cells, such as the ability of B cells, NK cells, T cells, keratinocytes in vitro, blooming cells, stellate cells, fibroblasts, neutrophils, endothelial beef and bland beef beef can aftermath il-1. The IL-1 contains a assertive bulk of alone skin, diaphoresis and urine of accustomed circumstances, the all-inclusive majority of beef in acknowledgment to a adopted antigen or mitogen dispatch to the amalgam and beard of il-1. IL-1 IL-1 has two altered atomic forms, a accepted IL-1 α, composed of 159 amino acids; addition is alleged IL-1 β, absolute 153 amino acids; both by altered genes encoding. Although the amino acerbic arrangement affection alone 26%, about IL-1 alpha and IL-1 beta in the aforementioned affection bounden to corpuscle apparent receptors play the same, the aforementioned biological action. IL-1 receptor ( IL-1R ) IL-1R exists in about all the apparent cells, the amount of IL-1R per corpuscle ranged, at atomic dozens ( such as T beef ), abounding bags of ( such as fibroblast ). IL-1R mainly has two types: one is il-1r1, the molecules into the cytoplasmic allocation of the best chain, plays a alteration activation arresting role; addition is il-1r2, peptide intracellular allocation is short, can not finer backpack signals, but the extracellular allocation of the peptide alternation absolution to the extracellular liquid, with chargeless anatomy and IL-1, apply a acknowledgment inhibition.
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