Anti-K-ras protein is film associated GTP/GDP bounden protein, atomic weight 21000, amid in the close membrane. It consists of 188 or 189 amino acids, the aboriginal area is awful conserved arrangement absolute 85 amino acerbic residues, area next absolute 80 amino acerbic residues, Ras protein anatomy is hardly different, in accession to the K2Ras terminal 25 amino acids due to altered exons and disconnected into A blazon and B type, the added associates of the Ras ancestors endure four amino acids are the actuality of 4 isoforms of Cys1862A2A2X2COOH arrangement of.Ras protein: H2Ras, N2Ras, K2Ras4A and K2Ras4B, they are the articles of 3 genes, including K2Ras4A and K2Ras4B is the aftereffect of the aforementioned gene another splicing of.Ras (P21) protein amid on the corpuscle membrane, which play an important role in the manual of corpuscle advance and adverse signals. It belongs to the three guanosine monophosphate (GTP) accumulated with egg white (a corpuscle advice manual coupling factor), through the GTP with guanosine monophosphate (two GDP) into anniversary added to adapt the alteration of advice of.P21 and GTP and GDP accept a able affinity, and GTP agitator action is weak. P21 and GDP beneath accustomed affairs with no activity, if extracellular advance credibility Of the signals to the corpuscle film P21, added P21 and GTP bounden action to P21 and GTP, accumulated into a accompaniment of activation, arresting system. Because P21 has the GTP agitator activity, can accomplish the hydrolysis of GTP to GDP, P21 and GDP accumulated with P21 inactivation, arresting arrangement is closed.
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