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3-Chloropyridine
CAS Number: 626-60-8
Molecular Weight: 113.54
Molecular Formula: C5H4ClN
Appearance colorless transparent liquid
Purity (HPLC, %) 99.0 min.
Moisture (%) 0.5 max.
Melting point (°C) 147 - 149  
3-Chloropyridine is primarily acclimated to accomplish added pyridine derivatives. Some bartering articles cover pyrithione, pyripropoxyfen, chlorphenamine, and disopyramide. These reactions await on chloride’s attributes as a acceptable abrogation accumulation to facilitate the alteration of a substrate assimilate the pyridine ring. Pyrithione, the conjugate abject of 2-mercaptopyridine-N-oxide, is a fungicide begin in some shampoos. It is generated from 2-chloropyridine by reacting the N-oxide of 2-chloropyridine with Na2S in a basal solution, afore abacus aqueous HCl] Acclimated as an antihistamine, pheniramine may be generated via several altered pathways. One amalgam is to hydroformylate functionalized olefins. This acknowledgment gain by reacting phenylacetonitrile with 2-chloropyridine in the attendance of a base. The consistent average is again alkylated by 2-(dimethylamino)ethyl chloride and the cyano accumulation removed.
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