N-benzoyl-L-phenylalaninol
Systematic name:Benzamide, N-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-
Molecular formulae :C16H17NO2
Molecular weight:255
Chemical abstracts number:4503-96-2
Bioassay-directed fractionation led to the abreast of seven compounds from a sample of the broiled leaves, twigs, and branches of Diospyros quaesitaThw. (Ebenaceae). One of the isolates, betulinic acerbic 3-caffeate (1), showed in vitro antimalarial action adjoin Plasmodium falciparum clones D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) with IC50 ethics of 1.40 and 0.98 μM, respectively. Evaluation of admixture 1 in the animal articulate epidermoid (KB) blight corpuscle band appear cytotoxicity at ED50 of 4.0 μM. In an attack to abate the cytotoxicity of 1, the acetylated acquired 1a and betulinic acerbic (1b) were prepared. Of the seven isolates, diospyrosin (2) was bent to be a new neolignan. In accession to 1, added accepted compounds abandoned in this abstraction were pinoresinol, lariciresinol, N-benzoyl-L-phenylalaninol, scopoletin, and poriferast-5-en-3β,7α-diol. The anatomy of 2 was elucidated based on spectroscopic abstracts assay including 1D- and 2D-NMR, and HR-ESI-MS.
The proposed anatomy of asperphenamate (1), a atypical fungal metabolite, was accepted by synthesis. Esterification of N-benzoyl-L-phenylalaninol with N-carbobenzoxy-L-phenylalanine, followed by deprotection of the carbobenzoxy accumulation and benzoylation yielded a artefact which was identical to the accustomed fungal metabolite.
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Systematic name:Benzamide, N-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-
Molecular formulae :C16H17NO2
Molecular weight:255
Chemical abstracts number:4503-96-2
Bioassay-directed fractionation led to the abreast of seven compounds from a sample of the broiled leaves, twigs, and branches of Diospyros quaesitaThw. (Ebenaceae). One of the isolates, betulinic acerbic 3-caffeate (1), showed in vitro antimalarial action adjoin Plasmodium falciparum clones D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) with IC50 ethics of 1.40 and 0.98 μM, respectively. Evaluation of admixture 1 in the animal articulate epidermoid (KB) blight corpuscle band appear cytotoxicity at ED50 of 4.0 μM. In an attack to abate the cytotoxicity of 1, the acetylated acquired 1a and betulinic acerbic (1b) were prepared. Of the seven isolates, diospyrosin (2) was bent to be a new neolignan. In accession to 1, added accepted compounds abandoned in this abstraction were pinoresinol, lariciresinol, N-benzoyl-L-phenylalaninol, scopoletin, and poriferast-5-en-3β,7α-diol. The anatomy of 2 was elucidated based on spectroscopic abstracts assay including 1D- and 2D-NMR, and HR-ESI-MS.
The proposed anatomy of asperphenamate (1), a atypical fungal metabolite, was accepted by synthesis. Esterification of N-benzoyl-L-phenylalaninol with N-carbobenzoxy-L-phenylalanine, followed by deprotection of the carbobenzoxy accumulation and benzoylation yielded a artefact which was identical to the accustomed fungal metabolite.
More about: N-benzoyl-L-phenylalaninol sale
Read more: Best Probiotics
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