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Nicotinic acid is one of 5 vitamins (when defective in animal diet) associated with an catching absence disease: niacin absence (pellagra), vitamin C absence (scurvy), thiamin absence (beriberi), vitamin D absence (rickets), vitamin A absence (night amaurosis and added symptoms). Niacin has been acclimated for over 50 years to access levels of HDL in the claret and has been begin to abundantly abatement the accident of cardiovascular contest in a amount of controlled animal trials.
Niacin binds to and stimulates a G-protein-coupled receptor, GPR109A, which causes the inhibition of fat breakdown in adipose tissue. Nicotinamide does not bind this receptor which explains why it does not affect claret lipid levels. Lipids that are absolved from adipose tissue are commonly acclimated to body very-low-density lipoproteins (VLDL) in the liver, which are precursors of low-density lipoprotein (LDL) or "bad" cholesterol. Because nicotinic acid blocks the breakdown of fats, it causes a abatement in chargeless blubbery acids in the claret and, as a consequence, decreases the beard of VLDL and cholesterol by the liver.
Pharmacological doses of niacin (1.5 - 6 g per day) occasionally advance to ancillary furnishings that can cover dermatological altitude such as derma bloom and itching, dry skin, and derma rashes including eczema deepening and acanthosis nigricans. Some of these affection are about accompanying to niacin's role as the amount attached cofactor in the histidine decarboxylase agitator which converts l-histidine into histamine. H1 and H2 receptor advised histamine is metabolized via a arrangement of address (or di-) amine oxidase and COMT into methylhistamine which is again conjugated through the liver's CYP450 pathways. Persistent bloom and added affection may announce deficiencies in one or added of the cofactors amenable for this enzymatic cascade. Gastrointestinal complaints, such as dyspepsia (indigestion), abhorrence and alarmist toxicity atomic hepatic failure, accept aswell been reported. Ancillary furnishings of hyperglycemia, cardiac arrhythmias and "birth defects in beginning animals" accept aswell been reported.
The alarmist can amalgamate niacin from the capital amino acerbic tryptophan, acute 60 mg of tryptophan to accomplish one mg of niacin. The 5-membered ambrosial heterocycle of tryptophan is broken and rearranged with the alpha amino accumulation of tryptophan into the 6-membered ambrosial heterocycle of niacin. Riboflavin, vitamin B6 and adamant are appropriate in some of the reactions complex in the about-face of tryptophan to NAD.
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