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Betahistine dihydrochloride is an anti-vertigo drug. It was first registered in Europe in 1970 for the treatment of Ménière's disease. It is commonly prescribed to patients with balance disorders or to alleviate vertigo symptoms associated with Ménière's disease.
Pharmacokinetics
Betahistine comes in both a tablet form as well as an oral solution, and is taken orally. It is rapidly and completely absorbed. The mean plasma half-life is 3–4 hours, and excretion is virtually complete in the urine within 24 hours. Plasma protein binding is very low. Betahistine is transformed into aminoethylpyridine and hydroxyethylpyridine and excreted with the urine as pyridylacetic acid. There is some evidence that one of these metabolites, aminoethylpyridine, may be active and exert effects similar to those of betahistine on ampullar receptors.
Mode of action
Betahistine has a very strong affinity as an antagonist for histamine H3 receptors and a weak affinity as an agonist for histamine H1 receptors. Betahistine seems to dilate the blood vessels within the inner ear which can relieve pressure from excess fluid and act on the smooth muscle.
Betahistine has two modes of action. Primarily, it has a direct stimulating (agonistic) effect on H1 receptors located on blood vessels in the inner ear. This gives rise to local vasodilation and increased permeability, which helps to reverse the underlying problem of endolymphatic hydrops.
More importantly, betahistine has a powerful antagonistic effects at H3 receptors, thereby increasing the levels of neurotransmitters histamine, acetylcholine, norepinephrine, and serotonin released from the nerve endings. The increased amounts of histamine released from histaminergic nerve endings can stimulate receptors. This stimulation explains the potent vasodilatory effects of betahistine in the inner ear, that are well documented.
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Name:2,6-dimercaptopurine
CAS: 5437-25-2
Molecular Formula:C5H4N4S2
Formula Weight:184.25
Description:
Melting point:> 300C
Boiling point:496.2 °C at 760 mmHg
Flash Point:253.9 °C
Density:1.8 g/cm3
Chemical property:Light yellow powder.slightly soluble in water.
Product Categories:Pyridines, Pyrimidines, Purines and Pteredines;Purine;API intermediates;Purines
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Name:2-chlorothiaxanthone
CAS: 86-39-5
Molecular Formula:C13H7ClOS
Formula Weight:     246.71
Description:
Melting point:152.5-153.5 °C
Boiling point:409.4 °C at 760 mmHg
Flash Point:201.4 °C
Density:1.417 g/cm3
Chemical property:yellow powder
Use:Serve as medicine intermediate.
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Erythropoietin, aswell accepted as EPO, is a glycoprotein hormone that controls erythropoiesis, or red claret corpuscle production. It is a cytokine (protein signaling molecule) for corpuscle (red claret cell) precursors in the cartilage marrow. Human EPO has a atomic weight of 34 kDa.
Also alleged hematopoietin or hemopoietin, it is produced by interstitial fibroblasts in the branch in abutting affiliation with peritubular capillary and tubular epithelial tubule. It is aswell produced in perisinusoidal beef in the liver. While alarmist assembly predominates in the fetal and perinatal period, renal assembly is absolute during adulthood. In accession to erythropoiesis, erythropoietin aswell has added accepted biological functions. For example, it plays an important role in the brain's acknowledgment to neuronal injury. EPO is aswell complex in the anguish healing process.
Exogenous erythropoietin is produced by recombinant DNA technology in corpuscle culture. Several adapted biologic agents are accessible with a array of glycosylation patterns, and are collectively alleged erythropoiesis-stimulating agents (ESA). The specific abstracts for labelled use alter amid the amalgamation inserts, but ESAs accept been acclimated in the analysis of anemia in abiding branch disease, anemia in myelodysplasia, and in anemia from blight chemotherapy. Boxed warnings cover a accident of death, myocardial infarction, stroke, venous thromboembolism, and bump recurrence. Exogenous erythropoietin has been acclimated illicitly as a performance-enhancing drug; it can about be detected in blood, due to slight differences from the autogenous protein, for example, in appearance of posttranslational modification.
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Name:Chloroquine diphosphate salt
CAS: 50-63-5
Molecular Formula:C18H32ClN3O8P2
Formula Weight:     515.86
Description:
Melting point:200 ºC
Boiling point:460.6 °C at 760 mmHg
Flash Point:232.3 °C
Chemical property:White Solid
Use:Used as antimalarial and amebacide
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Enzyme
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CAS : 136572-09-3
Name: Irinotecan monohydrochloride trihydrate
Use
Used in the analysis of tumors of the digestive system, such as stomach, colon, rectum, lung, and is acclimated to amusement leukemia, hydatidiform birthmark and choriocarcinoma. Irinotecan is a actinic anatomy modification of accustomed derivatives of camptothecin. It is beneath exact ability and ancillary furnishings of new blight drugs, mainly acclimated in the analysis of lung cancer, colorectal cancer, abdomen cancer, uterine cancer, ovarian blight and added cancers
Use
For the alertness of bang acclimated to amusement tumors of the digestive system, such as stomach, colon, rectum, lung, and is acclimated to amusement leukemia, hydatidiform birthmark and choriocarcinoma. Irinotecan is a actinic anatomy modification of accustomed derivatives of camptothecin. It is beneath exact ability and ancillary furnishings of new blight drugs, mainly acclimated in the analysis of lung cancer, colorectal cancer, abdomen cancer, uterine cancer, ovarian blight and added cancers.
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Name:Glysennide
CAS: 81-27-6
Molecular Formula:C42H38O20
Formula Weight:862.74
Description:
Melting point:200ºC-240ºC
Boiling point:1144.8 °C at 760 mmHg
Flash Point:348.6 °C
Density:1.743 g/cm3
Chemical property:Yellow Powder.Insoluble in water,benzene,ether and chloroform;Sparingly sol in methanol and acetone.
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Tenocyclidine (TCP) , is a dissociative anesthetic drug with psychostimulant and hallucinogenic effects. It is similar in effects to phencyclidine (PCP) but is considerably more potent. TCP has slightly different binding properties to PCP, with more affinity for the NMDA receptors, but less affinity for the sigma receptors.Because of its high affinity for the PCP site of the NMDA receptor complex, the 3H radiolabelled form of TCP is widely used in research into NMDA receptors.
TCP acts primarily as an NMDA receptor antagonist which blocks the activity of the NMDA receptor, however its increased psychostimulant effects compared to PCP suggests it also has relatively greater activity as a dopamine reuptake inhibitor (DRI).
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Name:2,5-dimethoxy-4-methylamphetamine
CAS:26011-50-7
Molecular Formula:C12H19NO2
Molecular Weight:209.29g/mol
Description:2, 5-dimethoxy-4-methylamphetamine is a psychedelic (hallucinogenic drug) and a substituted amphetamine.DOM is a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are mediated by its agonistic properties at the 5-HT2A receptor. Due to its selectivity, DOM is often used in scientific research when studying the 5-HT2 receptor subfamily.
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Ferritin is a all-over intracellular protein that food adamant and releases it in a controlled fashion. The protein is produced by about all active organisms, including algae, bacteria, college plants, and animals. In humans, it acts as a absorber adjoin adamant absence and adamant overload. Ferritin is begin in a lot of tissues as a cytosolic protein, but baby amounts are buried into the serum area it functions as an adamant carrier. Claret ferritin is aswell an aberrant brand of the absolute bulk of adamant stored in the body, appropriately serum ferritin is acclimated as a analytic analysis for adamant absence anemia.
Ferritin is a annular protein circuitous consisting of 24 protein subunits and is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, befitting adamant in a acrid and non-toxic form. Ferritin that is not accumulated with adamant is alleged apoferritin.
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