This gene encodes a affiliate of the STAT-induced STAT inhibitor (SSI), aswell accepted as suppressor of cytokine signalling (SOCS), family. SSI ancestors associates are cytokine-inducible abrogating regulators of cytokine signaling. The announcement of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ). The protein encoded by this gene functions after of cytokine receptors, and takes allotment in a abrogating acknowledgment bend to abate cytokine signaling. Knockout studies in mice appropriate the role of this gene as a modulator of IFN-γ action, which is appropriate for accustomed postnatal advance and survival.
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