Erythropoietin, aswell accepted as EPO, is a glycoprotein hormone that controls erythropoiesis, or red claret corpuscle production. It is a cytokine (protein signaling molecule) for corpuscle (red claret cell) precursors in the cartilage marrow. Human EPO has a atomic weight of 34 kDa.
Also alleged hematopoietin or hemopoietin, it is produced by interstitial fibroblasts in the branch in abutting affiliation with peritubular capillary and tubular epithelial tubule. It is aswell produced in perisinusoidal beef in the liver. While alarmist assembly predominates in the fetal and perinatal period, renal assembly is absolute during adulthood. In accession to erythropoiesis, erythropoietin aswell has added accepted biological functions. For example, it plays an important role in the brain's acknowledgment to neuronal injury. EPO is aswell complex in the anguish healing process.
Exogenous erythropoietin is produced by recombinant DNA technology in corpuscle culture. Several adapted biologic agents are accessible with a array of glycosylation patterns, and are collectively alleged erythropoiesis-stimulating agents (ESA). The specific abstracts for labelled use alter amid the amalgamation inserts, but ESAs accept been acclimated in the analysis of anemia in abiding branch disease, anemia in myelodysplasia, and in anemia from blight chemotherapy. Boxed warnings cover a accident of death, myocardial infarction, stroke, venous thromboembolism, and bump recurrence. Exogenous erythropoietin has been acclimated illicitly as a performance-enhancing drug; it can about be detected in blood, due to slight differences from the autogenous protein, for example, in appearance of posttranslational modification.
from:Acridine Raw Material
Also alleged hematopoietin or hemopoietin, it is produced by interstitial fibroblasts in the branch in abutting affiliation with peritubular capillary and tubular epithelial tubule. It is aswell produced in perisinusoidal beef in the liver. While alarmist assembly predominates in the fetal and perinatal period, renal assembly is absolute during adulthood. In accession to erythropoiesis, erythropoietin aswell has added accepted biological functions. For example, it plays an important role in the brain's acknowledgment to neuronal injury. EPO is aswell complex in the anguish healing process.
Exogenous erythropoietin is produced by recombinant DNA technology in corpuscle culture. Several adapted biologic agents are accessible with a array of glycosylation patterns, and are collectively alleged erythropoiesis-stimulating agents (ESA). The specific abstracts for labelled use alter amid the amalgamation inserts, but ESAs accept been acclimated in the analysis of anemia in abiding branch disease, anemia in myelodysplasia, and in anemia from blight chemotherapy. Boxed warnings cover a accident of death, myocardial infarction, stroke, venous thromboembolism, and bump recurrence. Exogenous erythropoietin has been acclimated illicitly as a performance-enhancing drug; it can about be detected in blood, due to slight differences from the autogenous protein, for example, in appearance of posttranslational modification.
from:Acridine Raw Material
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